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Myxedema Reference – Symptoms, Diagnosis, Treatments
Diseases & Treatments Section @ BillDoll.com – The Billion Dollar Site
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Myxedema Reference – Symptoms, Diagnoses, Treatments
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Myxedema-From Wikipedia, the free encyclopedia
Myxoedema Classification & external resources ICD-10 E00. — E03. ICD-9 244 DiseasesDB 6558 MedlinePlus 000353 eMedicine med/1581 derm/347 MeSH C19.874.482.638 Myxedema (British myxoedema) is a skin and tissue disorder usually due to severe prolonged hypothyroidism. Hypothyroidism can be caused by Hashimoto's thyroiditis, surgical removal of the thyroid, and rarer conditions. Partial forms of myxedema, especially of the lower legs (called pretibial myxedema), occasionally occur in adults with Graves' disease, a cause of hyperthyroidism; or also Hashimoto's thyroiditis without severe hypothyroidism.
Contents 1 Symptoms 2 Causes 3 Treatment 4 See also 5 External links
Symptoms Myxedema usually presents itself with some of the following symptoms:
Skin thickening Coarse skin Change in facial appearance Thickening nose Swollen lips Puffiness around the eyes Jelly-like infiltrations in subcutaneous tissues Slow speech Mental dullness Lethargy Mental problems Dry skin Yellow skin Swollen subcutaneous tissue Weight gain Constipation Thinning hair Brittle hair Bald patches Muscle pains Deafness Hearing impairment Carpal tunnel syndrome
Causes Myxedema stemming from both hyperthyroid and hypothyroid conditions, results from the accumulation of increased amounts of hyaluronic acid and chondroitin sulfate in the dermis in both lesional and normal skin. The mechanism that causes myxedema is still not yet understood, although animal model studies suggest that thyroid hormones affect the synthesis and catabolism of mucopolysaccharides and collagen by dermal fibroblasts. The fibroblasts in the orbital and pretibial dermis share antigenic sites that underlie the autoimmune process that causes Grave's disease. This cross-reaction may contribute to the development of myxedema long after normal levels of thyroid hormones have been restored by treatment.
Treatment Treatment for myxedema is difficult. Systemic or intralesional glucocorticoids, topical glucocorticoids under occlusion or high-dose intravenous immunoglobulin have been reported to offer some relief to patients. Treatment should follow correction of the original hyperthyroidism/hypothyroidism.
See also Cretinism - congenital hypothyroidism ..
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