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Hoodia & Obesity, Weight Loss – Reference & Directory

 

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Hoodia & Obesity, Weight Loss – Reference & Directory

 

Hoodia - From Wikipedia, the free encyclopedia

 

Hoodia gordonii

Scientific classification

Kingdom: Plantae

 

Division: Magnoliophyta

 

Class: Magnoliopsida

 

Order: Gentianales

 

Family: Apocynaceae

 

Subfamily: Asclepiadoideae

 

Tribe: Stapeliae

 

Genus: Hoodia

Sweet ex Decne.

 

Species

See below

 

Hoodia (IPA: 'hʊdiːə) is a genus of 13 species in the flowering plant family Apocynaceae, under the subfamily Asclepiadoideae.[1] They are stem succulents, described as "cactiform" because of their remarkable similarity to the unrelated cactus family. They can reach up to 1m high and have large flowers, often with flesh colour and strong smell.

 

Many Hoodia species are protected plants, typical of the Namib Desert, ranging from Central Namibia to southern Angola, especially in plains and rocky areas. Common names include "Bushman's Hat" and "Queen of the Namib". The indigenous Bushmen call this plant Xhoba (IPA: 'ɡəʊbə).

 

Several species are grown as garden plants, and one species, Hoodia gordonii, is being investigated for use as an appetite suppressant.

 

Contents

 

1 Species

2 Medicinal uses

2.1 Published scientific reports

2.2 Press coverage

2.3 Marketing and spam

3 References

4 External links

 

Species

 

Hoodia alstonii

Hoodia currorii (syn. H. lugardii, H. macrantha

Hoodia dregei

Hoodia flava

Hoodia gordonii (syn. Stapelia gordonii, H. barklyi, H. burkei, H. longispina)

Hoodia juttae

Hoodia mossamedensis

Hoodia officinalis (syn. H. delaetiana)

Hoodia parviflora

Hoodia pedicellata

Hoodia pilifera (syn. H. annulata, H. grandis, H. pillansii)

Hoodia ruschii (Queen of the Namib)

Hoodia triebneri (syn. H. foetida)

 

Medicinal uses

 

The use of Hoodia has long been known by the indigenous populations of Southern Africa, who infrequently use these plants for treating indigestion and small infections.

 

In 1977, the South African Council for Scientific and Industrial Research (CSIR) isolated the ingredient in hoodia - now known as P57 - which is responsible for its appetite-suppressant effect, and patented it in 1996. The CSIR then granted United Kingdom-based Phytopharm a license, and they collaborated with the pharmaceutical company Pfizer to isolate active ingredients from the extracts and look into synthesizing them for use as an appetite suppressant. Pfizer released the rights to the primary ingredient in 2002. Paul Hutson, associate professor in the University of Wisconsin-Madison School of Pharmacy, told the Wisconsin State Journal, "For Pfizer to release something dealing with obesity suggests to me that they felt there was no merit to its oral use". Pfizer states that development on P57, the active ingredient of Hoodia, was stopped due to the difficulty of synthesizing P57. Jasjit Bindra, lead researcher for hoodia at Pfizer, states there were indications of unwanted effects on the liver caused by other components, which could not be easily removed from the supplement, adding "Clearly, hoodia has a long way to go before it can earn approval from the Food and Drug Administration. Until safer formulations are developed, dieters should be wary of using it."

 

In 2002, CSIR officially recognized the San tribespeople’s rights over Hoodia, allowing them to take a percentage of the profits and any spin-offs resulting from the marketing of Hoodia. Hoodia gordonii is a protected plant which may only be wild-harvested by individuals and the few companies who have been granted a license.

 

Published scientific reports

 

It has not been scientifically proven if Hoodia works as an appetite suppressant. No published peer-reviewed double-blind clinical trials have been performed on humans to investigate the safety or effectiveness of Hoodia gordonii in pill form as a nutritional supplement.

 

One scientific study has been published in which the extract was injected directly into the brains of rats. The author of the rat study said that P57 was easily broken down by the liver, so it might be hard to take in enough of it to ensure that it had an effect. MacLean cautioned that currently available supplements might be inadequate, stating "I question whether there is really enough of the active ingredient in there to do much."

 

Press coverage

 

The press coverage and heavy marketing by nutritional supplement companies have created such a demand for Hoodia plants that a protected status was imposed in several countries like Namibia. Many products claiming to contain Hoodia do not actually contain the active ingredient alleged to suppress appetite. Only the South African product has the claimed properties. An ongoing review of Hoodia pills by Alkemists Pharmaceuticals found that at least half of the products advertised as containing Hoodia contained none.

 

In March 2006, Consumer Reports investigated the dietary supplement and concluded, "This weight loss drug lacks the clinical evidence for the Consumer Reports experts to recommend this product."

 

Marketing and spam

 

Lack of scientific evidence or regulatory approval have not stopped dietary supplement companies from marketing Hoodia gordonii extracts with claims that it can lower blood pressure and reduce the appetite. Goen Technologies Corporation's TrimSpa unit began marketing Hoodia gordonii under the brand name X32 with celebrity spokesperson Anna Nicole Smith, even though the Food and Drug Administration (FDA) has notified Trimspa that it has not demonstrated that claims for their product are scientifically supportable. Health Canada has not approved any hoodia products for sale. Goen Technologies has also been sued by the state of New Jersey for misleading consumers. The Trimspa brand is currently the subject of a lawsuit in California which claims that it does not contain any of Hoodia's active ingredient.

 

In March to June of 2006, billions of email spam messages were sent out concerning Hoodia, ostensibly offering Hoodia extracts for weight control purposes. As is usually the case with spam, it is not clear what prompted the sudden barrage of messages, since there had not been any recent positive media coverage about Hoodia, nor any signs of increasing public interest in Hoodia. The Federal Trade Commission has logged numerous complaints of consumer fraud associated with Hoodia and the number is expected to continue to rise.

 

In December 2004, Unilever entered into an agreement with Phytopharm to start marketing Hoodia gordonii commercially in the form of shakes and diet bars.

 

On July 1, 2006, it was reported on entertainment news show Extra that a company is now marketing Hoodia-enhanced lollipops called PowerPops.

 

There are many so-called "consumer research" websites claiming to show consumer reviews and testimonials. The legitimacy and accuracy of any of these websites are unknown. In addition to massive spam campaigns, there have been many reports of over-hyped and sometimes misleading marketing associated with websites selling and/or promoting Hoodia-related products.

 

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